Coprine, a cyclopropanone-related disulphiram-like constituent of Coprinus atramentarius
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Coprine, a cyclopropanone-related disulphiram-like constituent of Coprinus atramentarius isolation, structure, pharmacology and synthetic studies. by Per Lindberg

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Published by The Lund Inst. of Technology, Chemical Center in Lund .
Written in English


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Open LibraryOL20034796M

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  Improved fruiting of Coprinus atramentarius using cold-shock treatment during growth. World J Microbiol Biotechnol. 11(6) Tottmar O, Lindberg P. Effects on rat-liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, disulfiram-like constituent of Coprinus atramentarius. Acta Pharmacologica Et Toxicologica. 40(4) Coprine (N 5 -(1-hydroxycyclopropyl)-L-glutamine) is an inhibitor of aldehyde dehydrogenase (ALDH) in vivo. It has a rapid onset of action like cyanamide and demonstrates highest inhibition after 2–12 hours with a long duration of action like disulfiram with measurable inhibition after by: 9.   Tottmar O, Lindberg P. Effects on rat liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, the disulfiram-like constituent of Coprinus atramentarius. Acta Pharmacol Toxicol (Copenh) ;40(4)– CrossRef Google ScholarCited by: 1. &#x; The effect on the testis of the disulfiram-like compounds benzcoprine (N-[1-ethoxycyclopropyl] benzamide) and coprine (N 5-[1-hydroxycyclopropyl] -L-glutamine) was studied in rats and degeneration of the seminiferous epithelium was induced in rats by subacute oral administration of each compound. 60 days after termination of treatment with benzcoprine most Cited by:

Lindberg P, Bergman R, Wickberg B () Isolation and structure of coprine, a novel physiologically active cyclopropane derivative from Coprinus atramentarius and its synthesis via 1-amino-cyclo-propanol. J Chem Soc Chem Commun – Google ScholarCited by: 1. P. Lindberg, R. Bergman, B. WickbergIsolation and structure of coprine, a novel physiologically active cyclopropane derivertives from Coprinus atramentarius and its synthesis via 1-aminocyclopropanol J. Chem. Soc. Chem. : Hirokazu Kawagishi.   Tottmar O, Lindberg P. Effects on rat liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, the disulfiram-like constituent of Coprinus atramentarius. Acta Pharmacol Toxicol. ;– CrossRef Google Scholar. Lindberg, P., R. Bergman, and B. Wickberg: Isolation and Structure of Coprine, a Novel Physiologically Active Cyclopropanone Derivative from Coprinus atramentarius and its Synthesis via 1-Aminocyclopropanol. by:

31 Tottmar O, Lindberg P. Effects on rat liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, the disulfiram-like constituent of Coprinus atramentarius. Acta Cited by: 4. The Coprinus species (Coprinus atramentarius, a common lawn mushroom in particular), are often referred to as “inky caps” due to the black fluid that oozes from the cap of the mature mushroom. These mushrooms contain an amino acid coprine [N 5 - (1-hydroxycyclopropyl)–L-glutamine] (57, 59).Cited by:   Carlsson A, Henning M, Lindberg P, Martinson P, Trolin G, Waldeck B, et al. On the disulfiram-like effect of coprine, the pharmacologically active principle of Coprinus atramentarius. Acta Pharmacol Toxicol. ;–7. CrossRef Google Scholar. The disulphiram-like principle of the inky cap mushroom Coprinus atramentarius has been identified as N5-(1-hydroxycyclopropyl)-L-glutamine (coprine)(1).